Further Studies on the Bromodecarboxylation of Amino Acids with N-Bromosuccinimide

Further Studies on the Bromodecarboxylation Amino Acids with IV-Bromosuccinimide

In a previous publication from this laboratory, a method was described for the quantitative bromodecarboxylation of amino acids, proteins, and peptides (1). A review of decarboxylating compounds and of the theories pertinent to their mode of action has been presented by Schijnberg and Moubacher (2). The reaction of N-bromosuccinimide with various compounds in organic solvents has received consi...

The Bromodecarboxylation of Amino Acids: Formation of Nitriles* “r$

In previous papers from this laboratory (1, 2) it has been reported that a-amino acids undergo a quantitative decarboxylation.in aqueous solution when treated with N-bromosuccinimide. Under the conditions used\ (a temperature of 30” and a pH of 3 to 5), the reaction was complete in 30 minutes. Anomalies in behavior were observed with glycine and /3-alanine. The consumption of N-bromosuccinimide...

Flow injection chemiluminescence determination of amino acids by oxidation with N-bromosuccinimide.

The Decarboxylation of Amino Acids, Proteins, and Peptides by N-bromosuccinimide

One of the most widely used methods for the determination of amino acids is the ninhydrin technique perfected by Van Slyke and his coworkers (1). This permits the measurement of amino acid concentration either calorimetrically or by the volume of carbon dioxide released during the reaction. The measurement of carbon dioxide by the Van Slyke manometric apparatus is capable of great precision but...

The Bromodecarboxylation of Amino Acids: Formation of Nitriles* “r$ GEORGE W. STEVENSON AND J. MURRAY LUCK

In previous papers from this laboratory (1, 2) it has been reported that a-amino acids undergo a quantitative decarboxylation.in aqueous solution when treated with N-bromosuccinimide. Under the conditions used\ (a temperature of 30” and a pH of 3 to 5), the reaction was complete in 30 minutes. Anomalies in behavior were observed with glycine and /3-alanine. The consumption of N-bromosuccinimide...